生命分子研究部門分子科学研究所

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研究業績

学術論文

  1. T. SUZUKI, M. KAJINO, S. YANAKA，T. ZHU，H. YAGI，T. SATOH，T. YAMAGUCHI and K. KATO, "Conformational analysis of a high-mannose-type oligosaccharide displaying glucosyl determinant recognised by molecular chaperones using NMR-validated molecular dynamics simulation," ChemBioChem 18, 396-410 (2017).
  2. T. YOSHIMURA, A. HAYASHI, M. HANDA-NARUMI, H. YAGI, N. OHNO, T. KOIKE, Y. YAMAGUCHI, K. UCHIMURA, K. KADOMATSU, J. SEDZIK, K. KITAMURA, K. KATO, B.D. TRAPP, H. BABA and K. IKENAKA, "GlcNAc6ST-1 regulates sulfation of N-glycans and myelination in the peripheral nervous system," Sci. Rep. 7, Article number: 42257 (2017).
  3. M. NAGAE, S.K. MISHRA, M. NEYAZAKI, R. OI, A. IKEDA, N. MATSUGAKI, S. AKASHI, H. MANYA, M. MIZUNO, H. YAGI, K. KATO, T. SENDA, T. ENDO, T. NOGI and Y. YAMAGUCHI, "3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy," Genes Cells 22, 348-359 (2017).
  4. S. SAWAGUCHI, S. VERSHNEY, M. OGAWA, Y. SAKAIDANI, H. YAGI, K. TAKESHITA, T. MUROHARA, K. KATO, S. SUNDARAM, P. STANLEY and T. OKAJIMA, "O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals," eLife 6, e24419 (2017).
  5. E. KURIMORO, T. SATOH, Y. ITO, E. ISHIHARA, K. OKAMOTO, M. YAGI-UTSUMI, K. TANAKA and K. KATO, "Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation," Protein Sci. 26, 1080-1085 (2017).
  6. T. KATO, N. KAKO, K. KIKUTA, T. MIYAZAKI, S. KONDO, H. YAGI, K. KATO and E.Y. PARK, "N-Glycan modification of a recombinant protein via coexpression of human glycosyltransferases in silkworm pupae," Sci. Rep. 7, Article number: 1409 (2017).
  7. G. YAN, T. YAMAGUCHI, T. SUZUKI, S. YANAKA, S. SATO, M. FUJITA and K. KATO, "Hyper-assembly of self-assembled glycoclusters mediated by specific carbohydrate?carbohydrate interactions," Chem. Asian J. 12, 968-972 (2017).
  8. T. KATO, K. KIKUTA, A. KANEMATSU, S. KONDO, H. YAGI, K. KATO and E.Y. PARK, "Alteration of a recombinant protein N-glycan structure in silkworms by partial suppression of N-acetylglucosaminidase gene expression," Biotechnol. Lett. 39, 1299-1308 (2017).
  9. H. YAGI, H. TATENO, K. HAYASHI, T. HAYASHI, K. TAKAHASHI, J. HIRABAYASHI, K. KATO and M. TSUBOI, "Lectin microarray analysis of isolated polysaccharides from Sasa veitchii," Biosci. Biotechnol. Biochem. 81, 1687-1689 (2017).
  10. R. YOGO, S. YANAKA, H. YAGI, A. MARTEL, L. PORCAR, Y. UEKI, R. INOUE, N. SATO, M. SUGIYAMA and K. KATO, "Characterization of conformational deformation-coupled interaction between immunoglobulin G1 Fc glycoprotein and a low-affinity Fcγ receptor by deuteration-assisted small-angle neutron scattering," Biochem. Biophys. Rep. 12, 1-4 (2017).
  11. T. SATOH, C. SONG, T. ZHU, T. TOSHIMORI, K. MURATA, Y. HAYASHI, H. KAMIKUBO, T. UCHIHASHI and K. KATO, "Visualisation of a flexible modular structure of the ER folding-sensor enzyme UGGT," Sci. Rep. 7, Article number: 12142 (2017).
  12. S. KITAZAWA, M. YAGI-UTSUMI, K. KATO and R. KITAHARA, "Interactions controlling the slow dynamic conformational motions of ubiquitin," Molecules 22, Article number: 1414 (2017).
  13. S. YANAKA, T. YAMAZAKI, R. YOGO, M. NODA, S. UCHIYAMA, H. YAGI and K. KATO, "NMR detection of semi-specific antibody interactions in serum environments," Molecules 22, Article number: 1619 (2017).
  14. Y. SAKAE, T. SATOH, H. YAGI, S. YANAKA, T. YAMAGUCHI, Y. ISODA, S. IIDA, Y. OKAMOTO and K. KATO, "Conformational effects of N-glycan core fucosylation of immunoglobulin G Fc region on its interaction with Fcγ receptor IIIa," Sci. Rep. 7, Article number: 13780 (2017).
  15. T. TAKENAKA, T. NAKAMURA, S. YANAKA, M. YAGI-UTSUMI, M.S. CHANDAK, K. TAKAHASHI, S. PAUL, K. MAKABE, M. ARAI, K. KATO and K. KUWAJIMA, "Formation of the chaperonin complex studied by 2D NMR spectroscopy," PLOS ONE 12, e0187022 (2017).
  16. T. KOZAI, T. SEKIGUCHI, T. SATOH, H. YAGI, K. KATO and T. UCHIHASHI, "Two-step process for disassembly mechanism of proteasome α7 homo-tetradecamer by α6 revealed by high-speed atomic force microscopy," Sci. Rep. 7, Article number: 15373 (2017).

著書、総説

  1. Y. YAMAGUCHI, H. YAGI and K. KATO, "Stable isotope labeling of glycoproteins for NMR study," NMR in Glycoscience and Glycotechnology (K. Kato and T. Peters ed.), RSC Publishing (Cambridge), 194-207 (2017).
  2. M. YAGI-UTSUMI, T. YAMAGUCHI, Y. UEKUSA and K. KATO, "NMR characterization of the conformations, dynamics, and interactions of glycosphingolipids," NMR in Glycoscience and Glycotechnology (K. Kato and T. Peters ed.), RSC Publishing (Cambridge), 161-178 (2017).
  3. H. YAGI and K. KATO, "Functional roles of glycoconjugates in the maintenance of stemness and differentiation process of neural stem cells," Glycoconjugate J. 34, 757-763 (2017).

国際会議発表リスト

  1. KATO, M. YAGI-UTSUMI, S. YANAKA, T. SUZUKI, H. YAGI, T. SATOH and T. YAMAGUCHI, "NMR views of functional roles of glycoconjugates of biological and pharmaceutical interest," 7th Asia Pacific NMR Symposium & 23rd Annual Meeting of NMRS-India, Bangalore (India), February 2017.
  2. K. KATO, "Structural glycobiology by stable isotope-assisted NMR spectroscopy," Advances Isotopic Labeling Meeting for Integrated Structural Biology 2017, Grenoble (France), March 2017.
  3. R. YOGO, S. YANAKA, H. YAGI, M. SUGIYAMA and K. KATO, "Stable isotope-assisted biophysical characterisation of interaction between IgG-Fc and Fcγ receptor glycoproteins,” Advances Isotopic Labeling Meeting for Integrated Structural Biology 2017, Grenoble (France), March 2017.
  4. S. YANAKA, R. YOGO, H. YAGI, and K. KATO, "Stable isotope labelling for NMR observation of antibody glycoproteins in serum environments,” Advances Isotopic Labeling Meeting for Integrated Structural Biology 2017, Grenoble (France), March 2017.
  5. K. KATO, "Structural insights into dynamic orchestration of biomolecular systems," Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems, Taipei (Taiwan), April 2017.
  6. M. YAGI-UTSUMI, A. SIKDAR, T. SATOH and K. KATO, "Versatile structural architectures of archaeal homolog of proteasome assembly chaperone," Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems, Taipei (Taiwan), April 2017.
  7. K. KATO, "Structural basis of quality control and trafficking of glycoproteins," 24th International Symposium on Glycoconjugates (GLYCO24), Jeju (Korea), August 2017.
  8. S. YANAKA, "Integrative approach for exploration and creation of dynamical ordering of biomolecular systems," 14th HORIZONs in Molecular Biology, Göttingen (Germany),　September 2017.
  9. K. KATO, "Structural views of fate determination of glycoproteins in cells," Seminar at Max Planck Institute for Biophysical Chemistry, Göttingen (Germany), September 2017.
  10. S. YANAKA, "Stable isotope labeling for NMR observation of antibody glycoproteins in serum environments," Seminar at Max Planck Institute for Biophysical Chemistry, Göttingen (Germany), September 2017.
  11. K. KATO, M. YAGI-UTSUMI, S. YANAKA, T. SUZUKI, H. YAGI, T. SATOH, and T. YAMAGUCHI, "Structural mechanisms of carbohydrate functions," 2017 Taiwan-Japan Biomedical Symposium on Magnetic Resonance, Tainan (Taiwan), October 2017.
  12. K. KATO, "Dynamic ordering of biomolecular systems coupled with creation of integrated functions," The NANOTEC-IMS Joint Research Meeting, Pathum (Thailand), October 2017.
  13. K. KATO, "Dynamic ordering of biomolecular systems coupled with creation of integrated functions," CU-IMS collaborative seminar, Bangkok (Thailand), October 2017.
  14. K. KATO, "Structural aspects of glycosylation as potential drug target," The 19th Symposium on Advanced Concepts in New Drug Developmemt : 1st Ewha-NCU Joint Symposium, Seoul (Korea), November 2017.

招待講演

  1. K. KATO, M. YAGI-UTSUMI, S. YANAKA, T. SUZUKI, H. YAGI, T. SATOH and T. YAMAGUCHI, "NMR views of functional roles of glycoconjugates of biological and pharmaceutical interest," 7th Asia Pacific NMR Symposium & 23rd Annual Meeting of NMRS-India, Bangalore (India), February 2017.
  2. K. KATO, "Structural glycobiology by stable isotope-assisted NMR spectroscopy," Advances Isotopic Labeling Meeting for Integrated Structural Biology 2017, Grenoble (France), March 2017.
  3. 加藤晃一, "タンパク質の運命決定と機能発現の分子構造ダイナミクス研究," 細胞・システム作動機構の理解に向けた、生体タンパク質分子の構造と機能のダイナミクス研究の拠点形成 平成28年度末 シンポジウム, 岡崎, 2017年3月.
  4. 加藤晃一，谷中冴子，矢木宏和, "バイオ医薬品への構造生物学的アプローチ," 日本薬学会第137年会, 仙台, 2017年3月.
  5. K. KATO, "Structural insights into dynamic orchestration of biomolecular systems," Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems, Taipei (Taiwan), April 2017.
  6. M. YAGI-UTSUMI, A. SIKDAR, T. SATOH and K. KATO, "Versatile structural architectures of archaeal homolog of proteasome assembly chaperone," Frontier Bioorganization Forum 2017: Dynamical ordering and integrated functions of biomolecular systems, Taipei (Taiwan), April 2017.
  7. 矢木-内海真穂, "タンパク質の動的構造と分子集合メカニズムの理解を目指して," 第169回 薬学談話会, 名古屋, 2017年5月.
  8. 加藤晃一, "生体分子の集合離散が織りなす細胞機能研究の最前線," 第69回日本細胞生物学会大会, 仙台, 2017年6月.
  9. 加藤晃一, "抗体と糖鎖のNMR," NMR共用プラットフォームシンポジウム‐高磁場NMRを核としたプラットフォームの新たな展開‐, 横浜, 2017年8月.
  10. 加藤晃一, "プロテアソーム分子集合の構造生物学," 大阪大学蛋白質研究所セミナー・SPring-8先端利用技術ワークショップ SPring-8における蛋白質構造生物学研究の現状と将来, 吹田, 2017年8月.
  11. K. KATO, "Structural basis of quality control and trafficking of glycoproteins," 24th International Symposium on Glycoconjugates (GLYCO24), Jeju (Korea), August 2017.
  12. 加藤晃一, "糖鎖の生命分子科学の探究," 第11回分子科学討論会, 仙台, 2017年9月.
  13. 加藤晃一, "抗体を源流とする生命分子構造学の展開," 静岡県立大学薬学部 第264回 月例薬学セミナー, 静岡, 2017年9月.
  14. S. YANAKA, "Integrative approach for exploration and creation of dynamical ordering of biomolecular systems," 14th HORIZONs in Molecular Biology, Göttingen (Germany), September 2017.
  15. K. KATO, "Structural views of fate determination of glycoproteins in cells," Seminar at Max Planck Institute for Biophysical Chemistry, Göttingen (Germany), September 2017.
  16. S. YANAKA, "Stable isotope labeling for NMR observation of antibody glycoproteins in serum environments," Seminar at Max Planck Institute for Biophysical Chemistry, Göttingen (Germany), September 2017.
  17. K. KATO, M. YAGI-UTSUMI, S. YANAKA, T. SUZUKI, H. YAGI, T. SATOH, and T. YAMAGUCHI, "Structural mechanisms of carbohydrate functions," 2017 Taiwan-Japan Biomedical Symposium on Magnetic Resonance, Tainan (Taiwan), October 2017.
  18. K. KATO, "Dynamic ordering of biomolecular systems coupled with creation of integrated functions," The NANOTEC-IMS Joint Research Meeting, Pathum (Thailand), October 2017.
  19. K. KATO, "Dynamic ordering of biomolecular systems coupled with creation of integrated functions," CU-IMS collaborative seminar, Bangkok (Thailand), October 2017.
  20. K. KATO, "Isotope Labeling Approaches for Carbohydrates and Glycoproteins," 第56回NMR討論会, 八王子, 2017年11月.
  21. K. KATO, "Structural aspects of glycosylation as potential drug target," The 19th Symposium on Advanced Concepts in New Drug Developmemt : 1st Ewha-NCU Joint Symposium, Seoul (Korea), November 2017.
  22. 加藤晃一, "抗体への挑戦から始まった生命分子構造学の新展開," 鹿児島大学理学部先端科学講演会平成29年度第3回生命化学セミナー, 鹿児島, 2017年12月.
  23. 矢木真穂, "糖脂質膜上におけるタンパク質のアミロイド線維形成," 第2回 秩序化分子ワークショップ, 奈良, 2017年12月.

学会および社会的活動

  1. 学協会役員等
    日本バイオイメージング学会 評議員 (1995- ) 理事 (2012-2016).
    日本生化学学会 評議員 (2002- ) 代議員 (2005- ).
    日本糖質学会 評議員 (2003- ) 理事 (2013- ).
    日本核磁気共鳴学会評議員 (2006-2012, 2016-) 理事 (2008-2012, 2014-) 副会長(2016-2017).
    NPOバイオものづくり中部 理事 (2008-2017).
    日本蛋白質科学会 理事 (2010- 2014, 2015-) 副会長 (2016-).
    日本糖鎖科学コンソーシアム 幹事 (2012-) 常任幹事 (2016-).
    日本生物物理学会 委員(2013) 代議員(2014-2015).
    日本生化学会中部支部 幹事(2014-) 副支部長 (2016-).
  2. 学会の組織委員等
    The 71st Okazaki Conference “New perspectives on molecular science of glycoconjugates”組織委員 (2011).
    第51回NMR討論会運営委員 (2012).
    第27回生体系磁気共鳴国際会議(ICMRBS)実行委員 (2013-2016).
    第13回糖鎖科学コンソーシアムシンポジウム世話人代表 (2015).
    第25回バイオイメージング学会組織委員・大会長 (2016).
    第81回日本生化学会中部支部例会・シンポジウム世話人代表 (2017).
  3. 文部科学省、学術振興会、大学共同利用機関等の委員等
    日本学術振興会　科学研究費委員会専門委員 (2009- ).
    生物系特定産業技術研究支援センター イノベーション創出基礎的研究推進事業　書類審査専門委員 (2009- ).
    大阪大学蛋白質研究所専門委員会委員 (2014-) 同委員長 (2015).
    大阪大学蛋白質研究所「共同利用・共同研究」委員会超高磁場NMR共同利用・共同研究専門部会委員 (2012-).
    文部科学省研究振興局 委員会評価者 (2013- ).
    公益財団法人水谷糖質科学振興財団 選考委員 (2016-).
    日本学術会議　連携会員 (2017-).
  4. 学会誌編集委員
    Open Glycoscience, Editorial board member (2008-).
    Glycoconjugate Journal, Editorial board member (2009-).
    World Journal of Biological Chemistry, Editorial board member (2010-).
    Glycobiology, Editorial board member (2011-).
    Scientific Reports, Editorial board member (2015-).
    International Journal of Molecular Sciences, Editorial board member (2017-).

他大学での非常勤講師、客員教授

  1. お茶の水女子大学, 客員教授
  2. 名古屋市立大学薬学部, 大学院薬学研究科, 特任教授
  3. 理化学研究所, 客員研究員
  4. 国立長寿医療研究センター認知症先進医療開発センター, 客員研究員
  5. 名古屋大学大学院理学研究科、非常勤講師
  6. 静岡県立大学薬学研究院, 非常勤講師

受賞、表彰

  1. 谷中冴子, 第32回井上研究奨励賞 (2016).
  2. 谷中冴子, 第80回日本生化学会中部支部例会 奨励賞 (2016).
  3. 與語理那, OIIB retreat 2016 Best Poster Award (2016).
  4. 柚木康弘, 第4回将来を見据えた生体分子の構造・機能解析から分子設計に関する研究会 優秀発表賞 (2016).
  5. 谷中冴子, The 5th International Symposium of “Dynamical ordering of biomolecular systems for creation of integrated functions” Poster Presentation Award (2017).
  6. 柚木康弘, 第81回日本生化学会中部支部会 奨励賞 (2017).
  7. 與語理那, 第81回日本生化学会中部支部会 奨励賞 (2017).