細胞生理研究部門生理学研究所

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研究業績

学術論文

  1. M. Ohkita, S. Saito, T. Imagawa, K. Takahashi, M. Tominaga M and T. Ohta, "Molecular cloning and functiona characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveals its functional evolution for heat, acid and capsaicin sensitivities in terrestorial vertebrates" J. Biol. Chem., 287, 2388-2397 (2012).
  2. K. Shintaku, K. Uchida, Y. Suzuki, Y. Zhou, T. Fushiki, T. Watanabe, S. Yazawa and M. Tominaga, "Activation of TRPA1 by a non-pungent capsaicin-like compound, capsiate" Br. J. Pharmacol. 165, 1476-1486 (2012).
  3. T. Komatsu, K. Uchida, F. Fujita, Y. Zhou and M. Tominaga, "Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner" Pfluger Archiv. Eur. J. Physiol. 463, 549-559 (2012).
  4. H. Usuda, T. Endo, A. Shimouchi, A. Saito, M. Tominaga, H. Yamashita, H. Nagai, N. Inagaki and H. Tanaka, "Transient receptor potential vanilloid 1 - a polymodal nociceptive receptor ? plays a crutial role in formaldehyde-induced skin inflammation in mice" J. Pharmacol. Sci. 118, 266-274 (2012).
  5. N. Kida, T. Sokabe, M. Kashio, K. Haruna, Y. Mizuno, Y. Suga, K. Nishikawa, A. Kanamaru, M. Hongo, A. Oba and M. Tominaga, "Importance of transient receptor potential vanilloid 4 (TRPV4) in epidermal barrier function in human skin keratinocytes" Pfluger Archiv. Eur. J. Physiol. 463, 715-725 (2012).
  6. M. Kashio, T. Sokabe, K. Shintaku, T. Uematsu, N. Fukuta, N. Kobayashi, Y. Mori and M. Tominaga M, "Redox signal-mediated sensitization of Transient Receptor Potential Melastatin 2 (TRPM2) to temperature affects macrophage functions" Proc. Natl. Acad. Sci. USA 109, 6745-6750 (2012).
  7. Y. Kitagawa, A. Miyai, K. Usui, Y. Hamada, K. Deai, M. Wada, Y. Koga, M. Sakata, M. Hayashi, M. Tominaga and M. Matsushita, "Pharmacological characterization of (3S)-3-(hydroxymethyl)-4-(5-methylpyridin-2-yl)-N-[6-(2,2,2-trifluoro ethoxy)pyridin-3-yl]-3,4 -dihydro-2H-benzo[b][1,4]oxazine-8-carboxamide (JTS-653), a novel Transient Receptor Potential Vanilloid 1 antagonist" J. Pharmacol. Exp. Ther. 342, 520-528 (2012).
  8. H. Ogawa, K. Takahashi, S. Miura, T. Imagawa, S. Saito, M. Tominaga and T. Ohta, "H(2)S functions as a nociceptive messenger through Transient Receptor Potential Ankyrin 1 (Trpa1) activation" Neuroscience 218, 335-343 (2012).
  9. S. Saito, K. Nakatsuka, K. Takahashi, N. Fukuta, T. Imagawa, T. Ohta and M. Tominaga M, "Analysis of Transient Receptor Potential Ankyrin 1 (TRPA1) in frogs and lizards illuminates both nociceptive heat and chemical sensitivities and coexpression with TRP Vanilloid 1 (TRPV1) in ancestral vertebrates" J. Biol. Chem. 287, 30743-30754 (2012).
  10. K. Uchida, Y. Miura, M. Nagai and M. Tominaga, "Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel" Chemical Senses 37, 809-818 (2012).
  11. M. Takaishi, F. Fujita, K. Uchida, S. Yamamoto, M. Sawada, C. Hatai, M. Shimizu and M. Tominaga, "1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1" Molec. Pain 8, 86 (2012).
  12. K. Nagai, Y. Saitoh, S. Saito and K. Tsutsumi, "Structure and Hibernation-associated Expression of the Transient Receptor Potential Vanilloid 4 Channel (TRPV4) mRNA in the Japanese Grass Lizard (Takydromus tachydromoides) " Zoological Science 29,185-190 (2012).

著書，総説

  1. T. Tsunematsu and A. Yamanaka, "The role of orexin/hypocretin in the central nervous system and peripheral tissues" Vitam. Horm. 89, 19-33 (2012).
  2. 富永真琴，"酸味および辛み受容のメカニズム" 香料　254, 196-202 (2012).
  3. 富永真琴，"侵害受容性疼痛"　整形外科　63, 712-716 (2012).
  4. 木田尚子，曽我部隆彰，金丸晶子，富永真琴 "皮膚の温度センサーTRPV4を活性化する化粧品素材の開発"　アレルギーの臨床　32, 659-665 (2012).
  5. 富永真琴，"刺激感受性：温度感受性TRPチャネルの生理機能"　日本香粧品学会誌　36, 1-7 (2012).

国際会議発表リスト

  1. M. Tominaga, "Regulation of TRPA1 activity in pathological conditions" The 7th International Conference of Neurons and Brain Diseases, Montreal (Canada), June 2012.
  2. Saito "Functional evolution of nociceptive receptors TRPA1 and TRPV1 in vertebrates" Annual Meeting of Society for Molecular Biology and Evolution Dublin (Ireland) 2012.
  3. M. Kashio, "Redox signal-mediated sensitization of Transient Receptor Potential Melastatin 2 (TRPM2) to temperature affects macrophage functions" 4th International Congress on Cell membranes and Oxidative Stress Isparta (Turkey) 2012.
  4. T. Tsunematsu, "Long time silencing of orexin/　hypocretin neuronal activity using optogenetics in archaerhodopsin-3-expressing transgenic mice" 8th FENS Forum of Neuroscience Barcelona (Spain) 2012.
  5. M. Tominaga, "Physiological significance of TRPM2 channel and evolutional changes in the structure and function of thermosensitive TRP channels" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
  6. Y. Suzuki, "Epithelial TRP channels for maternal-fetal calcium transport" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
  7. K. Uchida, "The role of TRPM2 channel in pancreatic b-cell functions" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
  8. M. Kashio, "Redox signal mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
  9. Y. Zhou, "A novel alternative splicing variant of mouse TRPA1 regulates its channel activity under physiological and pathological conditions" 14th World Congress of Pain, Milan (Italy), August 2012.
  10. S. Tabuchi, "New model mice for narcolepsy using timing controlled gene expression system in transgenic mice which induces specific ablation of orexin/hypocretin neurons" Neuroscience 2012, (USA), October 2012.
  11. F. Fujita, "Modal shift of cool sensor TRPM8 by changing ambient temperature and its application to cosmetics" 27th Congress of International Federation of Societies of Cosmetic Chemists, Johannesburg (South Africa), October 2012.
  12. M. Tominaga, "Molecular mechanisms of nociception through TRPA1 activation" International Conference of Physiological Sciences, Suzhou (China), November 2012.
  13. T. Tsunematsu, "Optogenetic manipulation of orexin neuronal activity affects sleep/wakefulness state in mice" The 7th Asian Sleep Research Society Congress, Taipei (Taiwan), December 2012

招待講演

  1. 富永真琴「治療標的としての皮膚のTRPV3,TRPV4」、第85回日本薬理学会年会、京都、2012年3月.
  2. 山中章弘「オプトジェネティクスを用いたオレキシン神経活動抑制は徐波睡眠を誘導する」、第117回日本解剖学会全国学術集会、甲府、2012年3月.
  3. 富永真琴「刺激感受性：温度感受性TRPチャネルの生理機能」、第37回日本香粧品学会 、東京、2012年6月.
  4. M. Tominaga, "Physiological significance of TRPM2 channel and evolutional changes in the structure and function of thermosensitive TRP channels" 2012 International Ion Channel Conference, Jeju (Korea), August 2012.
  5. 富永真琴「TRPチャネルを介した侵害受容の分子機構」第32回鎮痛薬・オピオイドペプチドシンポジウム、東京、2012年9月.
  6. 富永真琴「動物におけるカルシウム透過性TRPチャネルを介した環境温度受容」日本植物学会第76回大会、姫路、2012年9月.
  7. 富永真琴「TRPV1, TRPA1チャネルを介した侵害受容とその制御機構」第42回日本臨床神経生理学会学術大会、東京、2012年11月.
  8. M. Tominaga, "Molecular mechanisms of nociception through TRPA1 activation" International Conference of Physiological Sciences, Suzhou (China), November 2012.
  9. 富永真琴「感覚神経に発現する温度感受性TRPチャネルの生理機能」第1回ニューロカンファレンス和歌山、和歌山、2012年12月.
  10. T. Tsunematsu, "Optogenetic manipulation of orexin neuronal activity affects sleep/wakefulness state in mice" The 7th Asian Sleep Research Society Congress, Taipei (Taiwan), December 2012.

学会および社会的活動　

  1. 日本生理学会理事（富永真琴）
  2. 日本生理学会会員委員会委員（富永真琴）
  3. 日本神経科学学会男女共同参画委員会委員（富永真琴）
  4. 国際疼痛学会倫理委員会委員（富永真琴）
  5. 日本疼痛学会理事（富永真琴）
  6. The Journal of Physiological Sciences, Editorial board member (M. Tominaga)
  7. Pfluger Archiv European Journal of Physiology, Editorial board member (M. Tominaga)
  8. Molecular Pain, Editorial board member (M. Tominaga)

他大学での非常勤講師、客員教授

  1. 三重大学大学院医学研究科 非常勤講師（富永真琴）
  2. 金沢大学医薬保健学域 非常勤講師（富永真琴）
  3. 九州大学歯学研究院 非常勤講師（富永真琴）
  4. 富山大学医学薬学教育部 非常勤講師（富永真琴）

受賞、表彰

  1. 第１６回食創会「安藤百福賞」