生物無機研究部門分子科学研究所

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研究業績

学術論文

  1. H. SAWAI, H. SUGIMOTO, Y. SHIRO, H. ISHIKAWA, Y. MIZUTANI and S. AONO, "Structural Basis for Oxygen Sensing and Signal Transduction of the Heme-based Sensor Protein Aer2 from Pseudomonas aeruginosa" Chem. Commun. 48, 6523-6525 (2012).
  2. S. EL-MASHTOLY, M. KUBO, Y. GU, H. SAWAI, S. NAKASIMA, T. OGURA, S. AONO and T. KITAGAWA, "Site-Specific Protein Dynamics in communication pathway from sensor to signaling domain of oxygen sensor protein, HemAT-Bs: time-resolved ultraviolet resonance Raman study" J. Biol. Chem. 287, 19973-19984 (2012).
  3. H. SAWAI*, M. YAMANAKA*, H. SUGIMOTO, Y. SHIRO and S. AONO, "Structural basis for the transcriptional regulation of heme homeostasis in Lactococcus lactis" J. Biol. Chem. 287, 30755-30768 (2012). (* equal contribution)
  4. Y. YOSHIDA, H. ISHIKAWA, S. AONO and Y. MIZUTANI, "Structural dynamics of proximal heme pocket in HemAT-Bs associated with O2 dissociation" Biochem. Biophys. Acta - Proteins and Proteomics 1824, 866-872 (2012).

総説，著書

  1. S. AONO, "Novel bacterial gas sensor proteins with transition-metal-containing prosthetic groups as active sites" Antioxd. Redox Signal. 16, 678-686 (2012).
  2. 青野重利, 「鉄分バランスを整える ?乳酸菌における細胞内ヘム濃度制御」，化学 67, 68-69 (2012).

国際会議発表リスト

  1. S. AONO, "Structural basis for the transcriptional regulation of heme homeostasis in Lactococcus lactis" 4th Japan-Korea Seminar on Biomolecular Sciences Experiments and Simulations, Nara (Japan), January 2012.
  2. S. AONO, "Transcriptional regulation by heme acting as a signaling molecule" 221st The Electrochemical Society Meeting, Seattle (U.S.A.), May 2012.
  3. S. AONO, "Structural basis for the transcriptional regulation of heme homeostasis in lactic acid bacterium, Lactococcus lactis" 7th International Conference on Porphyrins and Phthalocyanines (ICPP-7), Jeju (Korea), July 2012.
  4. S. AONO, H. SAWAI, M. YAMANAKA, H. SUGIMOTO, Y. SHIRO, "Structural basis for the transcriptional regulation of heme homeostasis in lactic acid bacteria" 8th International Biometals Symposium (Biometals 2012), Brussels (Belgium), July, 2012.
  5. H. SAWAI, M. YAMANAKA, H. SUGIMOTO, Y. SHIRO, S. AONO, "Crystal structures of heme-sensing transcriptional regulator responsible for heme homeostasis in Lactococcus lactis" 11th European Biological Inorganic Chemistry Conference (Eurobic 11), Granada (Spain), September, 2012.
  6. H. SAWAI, H. SUGIMOTO, Y. KATO, Y. ASANO, Y. SHIRO, S. AONO, "X-ray crystal structure of Michaelis complex of aldoxime dehydratase, a new heme-containing hydrolyase" EMBO Conference: Catalytic Mechanisms by Biological Systems, Groningen (The Netherlands), October, 2012.
  7. S. AONO, "Molecular mechanism of heme-responsive transcriptional regulation" 6th Asian Biological Inorganic Chemistry Conference (AsBIC-6), Hong Kong (China), November 2012.
  8. H. SAWAI, M. YAMANAKA, H. SUGIMOTO, Y. SHIRO, S. AONO, "Structural basisi for the transcriptional regulation of heme homeostasis in Lactococcus lactis" The 1st International Symposium on Biofunctional Chemistry (ISBC2012), Tokyo (Japan), November, 2012.
  9. H. SAWAI, H. SUGIMOTO, Y. SHIRO, S. AONO, "Structural Basis for Oxygen Sensing and Signal Transduction of the Heme-based Sensor Protein Aer2" 5th Korea-Japan Seminar on Biomolecular Sciences Experiments and Simulations, Seoul (Korea), February, 2013.

招待講演

  1. S. AONO, "Structural basis for the transcriptional regulation of heme homeostasis in Lactococcus lactis" 4th Japan-Korea Seminar on Biomolecular Sciences Experiments and Simulations, Nara (Japan), January 2012.
  2. S. AONO, "Transcriptional regulation by heme acting as a signaling molecule" 221st The Electrochemical Society Meeting, Seattle (U.S.A.), May 2012.
  3. S. AONO, "Structural basis for the transcriptional regulation of heme homeostasis in lactic acid bacterium, Lactococcus lactis" 7th International Conference on Porphyrins and Phthalocyanines (ICPP-7), Jeju (Korea), July 2012.
  4. S. AONO, "Molecular mechanism of heme-responsive transcriptional regulation" 6th Asian Biological Inorganic Chemistry Conference (AsBIC-6), Hong Kong (China), November 2012.
  5. H. SAWAI, H. SUGIMOTO, Y. SHIRO, S. AONO, "Structural Basis for Oxygen Sensing and Signal Transduction of the Heme-based Sensor Protein Aer2" 5th Korea-Japan Seminar on Biomolecular Sciences Experiments and Simulations, Seoul (Korea), February, 2013.

学会および社会的活動

  1. 学協会役員等
    触媒学会生体関連触媒研究会世話人　(2002- ).
    日本化学会生体機能関連化学部会幹事　(2007- ).
    日本化学会東海支部常任幹事　(2009-2010).
  2. 学会の組織委員等
    14th International Conference on BiologicalInorganic Chemistry組織委員会総務委員長 (2009).
    The first International Symposium on Biofunctional Chemistry組織委員 (2012).
    Japan-Korea Seminar on Biomolecular Sciences -Experiments and Simulations組織委員(2008-2010, 2012).
  3. 文部科学省,学術振興会,大学共同利用機関等の委員等
    日本学術振興会特別研究員等審査会専門委員 (2005-2007).
    日本学術振興会国際事業委員会書面審査委員 (2005-2007).
    日本学術振興会科学研究費委員会専門委員 (2010-2012)
  4. 学会誌編集委員
    J. Biol. Inorg. Chem., Editorial Advisory Board (2002-2004).
    Biosensors, Editorial Board (2010- ).