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Biomolecular Science

Koichi Kato(Prof.)
Takumi Yamaguchi (Assis. Prof.) Maho Yagi(Research Assis. Prof.)


Elucidation of the Mechanisms Underlying Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions

Living systems are characterized as dynamic processes of assembly and disassembly of various biomolecules that are self-organized, interacting with the external environment. The omics-based approaches developed in recent decades have provided comprehensive information regarding biomolecules as parts of living organisms. However, fundamental questions still remain unsolved as to how these biomolecules are ordered autonomously to form flexible and robust systems. We develop multidisciplinary research area, including fields of biology, chemistry, physics, and aims to elucidate the mechanisms underlying the dynamic ordering of biomolecules for the creation of integrated functions.

Formation of supramolecular machinery through dynamic assembly
and disassembly of biomolecules


  1. T.Yamaguchi, T.Uno, Y.Uekusa, M.Yagi-Utsumi, and K.Kato, "Ganglioside-embedding small bicelles for probing membrane-landing processes of intrinsically disordered proteins," Chem. Commun. 49, 1235-1237 (2013)
  2. K.Kumoi, T.Satoh, K.Murata, T.Hiromoto, T.Mizushima, Y.Kamiya, M.Noda, S.Uchiyama, H.Yagi, and K.Kato, "An archaeal homolog of proteasome assembly factor functions as a proteasome activator," PLoS ONE 8, e60294 (2013)
  3. M.Yagi-Utsumi, T.Kunihara, T.Nakamura, Y.Uekusa, K.Makabe, K.Kuwajima, and K.Kato, "NMR characterization of the interaction of GroEL with amyloidβ as a model ligand," FEBS Lett. 587, 1605-1609 (2013)
  4. E.Kurimoto, K.Kuroki, Y.Yamaguchi, M.Yagi-Utsumi, T.Igaki, T.Iguchi, K.Maenaka, and K.Kato, "Structural and functional mosaic nature of MHC class I molecules in their peptide-free form," Mol. Immunol. 55, 393-399 (2013)
  5. H.Yagi, N.Nakagawa, T.Saito, H.Kiyonari, T.Abe, T.Toda, S.W.Wu, K.H.Khoo, S. Oka, and K.Kato, "AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan," Sci. Rep. 3, Article number: 3288 (2013)


Okazaki Institute for Integrative Bioscience
5-1 Higashiyama Myodaijichou Okazaki Aichi